Ontology highlight
ABSTRACT:
SUBMITTER: Spizzo R
PROVIDER: S-EPMC3648637 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Spizzo R R Nicoloso M S MS Lupini L L Lu Y Y Fogarty J J Rossi S S Zagatti B B Fabbri M M Veronese A A Liu X X Davuluri R R Croce C M CM Mills G G Negrini M M Calin G A GA
Cell death and differentiation 20090904 2
Understanding the consequences of miR-145 reintroduction in human breast cancer (BC) could reveal its tumor-suppressive functions and may disclose new aspects of BC biology. Therefore, we characterized the effects of miR-145 re-expression in BC cell lines by using proliferation and apoptosis assays. As a result, we found that miR-145 exhibited a pro-apoptotic effect, which is dependent on TP53 activation, and that TP53 activation can, in turn, stimulate miR-145 expression, thus establishing a de ...[more]