Unknown

Dataset Information

0

Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates.


ABSTRACT: The development of an effective AIDS vaccine remains a challenge. Nucleoside-modified mRNAs formulated in lipid nanoparticles (mRNA-LNP) have proved to be a potent mode of immunization against infectious diseases in preclinical studies, and are being tested for SARS-CoV-2 in humans. A critical question is how mRNA-LNP vaccine immunogenicity compares to that of traditional adjuvanted protein vaccines in primates. Here, we show that mRNA-LNP immunization compared to protein immunization elicits either the same or superior magnitude and breadth of HIV-1 Env-specific polyfunctional antibodies. Immunization with mRNA-LNP encoding Zika premembrane and envelope or HIV-1 Env gp160 induces durable neutralizing antibodies for at least 41 weeks. Doses of mRNA-LNP as low as 5 μg are immunogenic in macaques. Thus, mRNA-LNP can be used to rapidly generate single or multi-component vaccines, such as sequential vaccines needed to protect against HIV-1 infection. Such vaccines would be as or more immunogenic than adjuvanted recombinant protein vaccines in primates.

SUBMITTER: Saunders KO 

PROVIDER: S-EPMC8035178 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC6002853 | biostudies-literature
| S-EPMC4502585 | biostudies-literature
| S-EPMC8312026 | biostudies-literature
| S-EPMC4467030 | biostudies-literature
| S-EPMC4565490 | biostudies-literature
| S-EPMC8132231 | biostudies-literature
| S-EPMC8651551 | biostudies-literature
| S-EPMC7978427 | biostudies-literature
| S-EPMC3649569 | biostudies-literature
| S-EPMC6597128 | biostudies-literature