Ontology highlight
ABSTRACT:
SUBMITTER: Miyashita T
PROVIDER: S-EPMC3651368 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Miyashita Tomoyuki T Oda Yoshiaki Y Horiuchi Junjiro J Yin Jerry C P JC Morimoto Takako T Saitoe Minoru M
Neuron 20120601 5
NMDA receptor (NMDAR) channels allow Ca(2+) influx only during correlated activation of both pre- and postsynaptic cells; a Mg(2+) block mechanism suppresses NMDAR activity when the postsynaptic cell is inactive. Although the importance of NMDARs in associative learning and long-term memory (LTM) formation has been demonstrated, the role of Mg(2+) block in these processes remains unclear. Using transgenic flies expressing NMDARs defective for Mg(2+) block, we found that Mg(2+) block mutants are ...[more]