Ontology highlight
ABSTRACT:
SUBMITTER: Fang Y
PROVIDER: S-EPMC3651624 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Fang Yi Y Yu Xiaofang X Liu Yong Y Kriegel Alison J AJ Heng Yanyan Y Xu Xialian X Liang Mingyu M Ding Xiaoqiang X
American journal of physiology. Renal physiology 20130306 10
Treatment with L-mimosine, which activates hypoxia-inducible factor-α (HIF-α), attenuates renal tubulointerstitial injury and improves renal function in a rat remnant kidney model. The miR-29 family of microRNAs directly targets a large number of extracellular matrix genes and reduces renal interstitial fibrosis. We analyzed microRNA expression profiles in rat remnant kidneys with or without treatment with L-mimosine. The expression of miR-29c was downregulated in rat remnant kidneys compared wi ...[more]