Ontology highlight
ABSTRACT:
SUBMITTER: Chan DA
PROVIDER: S-EPMC3652585 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Chan Denise A DA Giaccia Amato J AJ
Nature reviews. Drug discovery 20110501 5
Unique features of tumours that can be exploited by targeted therapies are a key focus of current cancer research. One such approach is known as synthetic lethality screening, which involves searching for genetic interactions of two mutations whereby the presence of either mutation alone has no effect on cell viability but the combination of the two mutations results in cell death. The presence of one of these mutations in cancer cells but not in normal cells can therefore create opportunities t ...[more]