Ontology highlight
ABSTRACT:
SUBMITTER: Shieh GS
PROVIDER: S-EPMC8779047 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Journal of personalized medicine 20220112 1
Two genes are said to have synthetic lethal (SL) interactions if the simultaneous mutations in a cell lead to lethality, but each individual mutation does not. Targeting SL partners of mutated cancer genes can kill cancer cells but leave normal cells intact. The applicability of translating this concept into clinics has been demonstrated by three drugs that have been approved by the FDA to target PARP for tumors bearing mutations in BRCA1/2. This article reviews applications of the SL concept to ...[more]