Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC3656168 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Li Hao H Wu Qi Q Li Jun J Yang PingAr P Zhu Zilu Z Luo Bao B Hsu Hui-Chen HC Mountz John D JD
Journal of immunology (Baltimore, Md. : 1950) 20130329 9
Marginal zone macrophages (MZMs) act as a barrier to entry of circulating apoptotic debris into the follicles of secondary lymphoid organs. In autoimmune BXD2 mice, there is a progressive reduction in the function and numbers of MZMs. Absence of MZMs results in retention of apoptotic cell (AC) debris within the marginal zone (MZ) and increased loading of AC Ags on MZ B cells and MZ-precursor (MZ-P) B cells. The MZ-P B cells are capable of translocating the AC Ags to the follicular zone and stimu ...[more]