Ontology highlight
ABSTRACT:
SUBMITTER: Nance JP
PROVIDER: S-EPMC4456636 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Nance J Philip JP Bélanger Simon S Johnston Robert J RJ Takemori Toshitada T Crotty Shane S
Journal of immunology (Baltimore, Md. : 1950) 20150508 12
T follicular helper (Tfh) cells are essential for germinal centers (GCs) and most long-term humoral immunity. Differentiation of Tfh cells depends on the transcriptional repressor B cell CLL/lymphoma 6 (Bcl6). Bcl6 mediates gene repression via the recruitment of corepressors. Currently, it is unknown how Bcl6 recruits corepressors to regulate gene expression of Tfh cells. In this article, we demonstrate, using a mutant form of Bcl6 with two BTB (bric-a-brac, tramtrack, broad-complex) mutations t ...[more]