Ontology highlight
ABSTRACT:
SUBMITTER: Liu W
PROVIDER: S-EPMC3660885 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Liu Weizhi W Boggon Titus J TJ
Acta crystallographica. Section F, Structural biology and crystallization communications 20130427 Pt 5
Integrin cytoplasmic domain-associated protein-1 (ICAP1) is a suppressor of integrin activation and directly binds to the cytoplasmic tail of β1 integrins; its binding suppresses integrin activation by competition with talin. Krev/Rap1 interaction trapped-1 (KRIT1) releases ICAP1 suppression of integrin activation by sequestering ICAP1 away from integrin cytoplasmic tails. Here, the cocrystal structure of the PTB domain of ICAP1 in complex with a 29-amino-acid fragment (residues 170-198) of KRIT ...[more]