Ontology highlight
ABSTRACT:
SUBMITTER: Xia H
PROVIDER: S-EPMC7395448 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Xia Hongjie H Xie Xuping X Zou Jing J Noble Christian G CG Russell William K WK Holthauzen Luis Marcelo F LMF Choi Kyung H KH White Mark A MA Shi Pei-Yong PY
Proceedings of the National Academy of Sciences of the United States of America 20200715 30
Dengue virus (DENV) was designated as a top 10 public health threat by the World Health Organization in 2019. No clinically approved anti-DENV drug is currently available. Here we report the high-resolution cocrystal structure (1.5 Å) of the DENV-2 capsid protein in complex with an inhibitor that potently suppresses DENV-2 but not other DENV serotypes. The inhibitor induces a "kissing" interaction between two capsid dimers. The inhibitor-bound capsid tetramers are assembled inside virions, resul ...[more]