Ontology highlight
ABSTRACT:
SUBMITTER: Zwahlen C
PROVIDER: S-EPMC310220 | biostudies-literature | 2000 Apr
REPOSITORIES: biostudies-literature
Zwahlen C C Li S C SC Kay L E LE Pawson T T Forman-Kay J D JD
The EMBO journal 20000401 7
The phosphotyrosine-binding (PTB) domain of the cell fate determinant Numb is involved in the formation of multiple protein complexes in vivo and can bind a diverse array of peptide sequences in vitro. To investigate the structural basis for the promiscuous nature of this protein module, we have determined its solution structure by NMR in a complex with a peptide containing an NMSF sequence derived from the Numb-associated kinase (Nak). The Nak peptide was found to adopt a significantly differen ...[more]