Ontology highlight
ABSTRACT:
SUBMITTER: Tateya S
PROVIDER: S-EPMC3661609 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Tateya Sanshiro S Rizzo-De Leon Norma N Handa Priya P Cheng Andrew M AM Morgan-Stevenson Vicki V Ogimoto Kayoko K Kanter Jenny E JE Bornfeldt Karin E KE Daum Guenter G Clowes Alexander W AW Chait Alan A Kim Francis F
Diabetes 20130124 6
Activation of AMP-activated protein kinase (AMPK) signaling reduces hepatic steatosis and hepatic insulin resistance; however, its regulatory mechanisms are not fully understood. In this study, we sought to determine whether vasodilator-stimulated phosphoprotein (VASP) signaling improves lipid metabolism in the liver and, if so, whether VASP's effects are mediated by AMPK. We show that disruption of VASP results in significant hepatic steatosis as a result of significant impairment of fatty acid ...[more]