Ontology highlight
ABSTRACT:
SUBMITTER: Lee J
PROVIDER: S-EPMC4927362 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Lee Jieun J Choi Joseph J Scafidi Susanna S Wolfgang Michael J MJ
Cell reports 20160616 1
The liver is critical for maintaining systemic energy balance during starvation. To understand the role of hepatic fatty acid β-oxidation on this process, we generated mice with a liver-specific knockout of carnitine palmitoyltransferase 2 (Cpt2(L-/-)), an obligate step in mitochondrial long-chain fatty acid β-oxidation. Fasting induced hepatic steatosis and serum dyslipidemia with an absence of circulating ketones, while blood glucose remained normal. Systemic energy homeostasis was largely mai ...[more]