Accurate identification of human Alu and non-Alu RNA editing sites.
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ABSTRACT:
SUBMITTER: Ramaswami G
PROVIDER: S-EPMC3662811 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Publications
Accurate identification of human Alu and non-Alu RNA editing sites.
Ramaswami Gokul G Lin Wei W Piskol Robert R Tan Meng How MH Davis Carrie C Li Jin Billy JB
Nature methods 20120404 6
We developed a computational framework to robustly identify RNA editing sites using transcriptome and genome deep-sequencing data from the same individual. As compared with previous methods, our approach identified a large number of Alu and non-Alu RNA editing sites with high specificity. We also found that editing of non-Alu sites appears to be dependent on nearby edited Alu sites, possibly through the locally formed double-stranded RNA structure. ...[more]
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