Genome sequence-independent identification of RNA editing sites.
Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Q
PROVIDER: S-EPMC4382388 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
Genome sequence-independent identification of RNA editing sites.
Nature methods 20150302 4
RNA editing generates post-transcriptional sequence changes that can be deduced from RNA-seq data, but detection typically requires matched genomic sequence or multiple related expression data sets. We developed the GIREMI tool (genome-independent identification of RNA editing by mutual information; https://www.ibp.ucla.edu/research/xiao/GIREMI.html) to predict adenosine-to-inosine editing accurately and sensitively from a single RNA-seq data set of modest sequencing depth. Using GIREMI on exist ...[more]
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