Ontology highlight
ABSTRACT:
SUBMITTER: Watanabe K
PROVIDER: S-EPMC3663144 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Watanabe Kaori K Al-Bassam Sarmad S Miyazaki Yusuke Y Wandless Thomas J TJ Webster Paul P Arnold Don B DB
Cell reports 20121213 6
Trafficking of proteins specifically to the axonal or somatodendritic membrane allows neurons to establish and maintain polarized compartments with distinct morphology and function. Diverse evidence suggests that an actin-dependent vesicle filter within the axon initial segment (AIS) plays a critical role in polarized trafficking; however, no distinctive actin-based structures capable of comprising such a filter have been found within the AIS. Here, using correlative light and scanning electron ...[more]