Ontology highlight
ABSTRACT:
SUBMITTER: Jones SL
PROVIDER: S-EPMC3987141 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Jones Steven L SL Korobova Farida F Svitkina Tatyana T
The Journal of cell biology 20140407 1
The axon initial segment (AIS) of differentiated neurons regulates action potential initiation and axon-dendritic polarity. The latter function depends on actin dynamics, but actin structure and functions at the AIS remain unclear. Using platinum replica electron microscopy (PREM), we have characterized the architecture of the AIS cytoskeleton in mature and developing hippocampal neurons. The AIS cytoskeleton assembly begins with bundling of microtubules and culminates in formation of a dense, f ...[more]