Dataset Information

SNP rs3825214 in TBX5 is associated with lone atrial fibrillation in Chinese Han population.

ABSTRACT:

Background

A prolonged PR interval is a sign of increased risk of cardiac arrhythmia. Recent genome-wide association studies found that the single-nucleotide polymorphism (SNP) rs3825214 in T-box 5 (TBX5) was positively associated with PR interval, QRS duration, QT interval, and common arrhythmia disorders such as atrial fibrillation (AF) and advanced atrioventricular block. However, other independent replication studies are required to validate the result. This study assessed associations between rs3825214 and ECG parameters, AF, and ventricular tachycardia (VT) in a Chinese Han population.

Methodology/principal findings

To assess the association between rs3825214 and AF and VT, we carried out case-control association studies with 692 AF patients (including 275 lone AF patients), 235 VT patients, and 856 controls. Genotyping was performed using a Rotor-Gene TM 6000 High Resolution Melt system. Statistical analyses of associations were adjusted for potential confounding factors. A moderate association was detected between rs3825214 and AF (P(adj)?=?0.036, OR?=?0.79) and a highly significant association was detected between the G allele of rs3825214 and lone AF (P(adj)?=?0.001, OR?=?0.65; genotypic P?=?3.75×10?? with a dominant model). We also found that rs3825214 showed a significant association with atrial-ventricular block (AVB; P?=?0.028; P(adj)?=?0.035, OR?=?0.494).

Conclusions

Our results indicate that rs3825214 conferred a significant risk of lone AF in this Chinese Han population.

SUBMITTER: Zang X

PROVIDER: S-EPMC3663751 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

SNP rs3825214 in TBX5 is associated with lone atrial fibrillation in Chinese Han population.

Zang Xiaobiao X Zhang Shulong S Xia Yunlong Y Li Sisi S Fu Fenfen F Li Xiuchun X Wang Fan F Zhang Rongfeng R Tian Xiaochen X Gao Lianjun L Zhang Jiaying J Yang Yanzong Y Tu Xin X Wang Qing Q

PloS one 20130524 5

<h4>Background</h4>A prolonged PR interval is a sign of increased risk of cardiac arrhythmia. Recent genome-wide association studies found that the single-nucleotide polymorphism (SNP) rs3825214 in T-box 5 (TBX5) was positively associated with PR interval, QRS duration, QT interval, and common arrhythmia disorders such as atrial fibrillation (AF) and advanced atrioventricular block. However, other independent replication studies are required to validate the result. This study assessed associatio ...[more]

PMID: 23717681

Similar Datasets

Project description:BackgroundPR interval variations have recently been associated with an increased risk of long-term atrial fibrillation (AF), heart block and all-cause mortality. Genome-wide association studies have linked the PR interval with several common variants in the TBX5 gene. Several variants in the TBX5 gene, including rs7312625 and rs883079, have been associated with AF. The purpose of this study was to determine the association of single-nucleotide polymorphisms (SNPs) in the TBX5 gene, rs7312625 and rs883079, with AF in Chinese Han patients.Methodology/principal findingsIn this case-control association study, large cohorts of AF patients (n = 1132) and controls (n = 1206) were recruited from different hospitals. The genotyping was performed using a Rotor-Gene TM 6000 high-resolution melt system. Rs7312625, rs3825214 and rs883079 were analyzed. We found that SNP 3825214 was significantly associated with AF (P-obs = 0.002, odds ratio [OR] = 0.82), and lone AF (P-obs = 6.77x10-5, odds ratio [OR] = 0.71). SNP rs7312625 was significantly associated with lone AF (P-obs = 0.015, odds ratio [OR] = 1.27), although its association with AF was not significant. No significant association of SNP rs883079 with AF or lone AF was observed. Thus, we analyzed the interaction among these three loci. We demonstrated significant interaction among rs3825214, rs7312625 and rs883079. Four-locus risk alleles showed the highest odds ratio in combined rs3825214 and rs7312625 (P-obs<0.0001, odds ratio [OR] = 2.21). Six-locus risk alleles showed the highest odds ratio in combined rs3825214, rs7312625 and rs 883079(P-obs<0.0001, odds ratio [OR] = 2.35). Significance was established with the trend test (P<0.0001).ConclusionsFor the first time, we report the strong association of SNP rs3825214 in the TBX5 gene with AF and lone AF in a Chinese Han population. Rs7312625 was significantly associated with lone AF, and snp-snp interaction increased the risk of atrial fibrillation. Our data might provide new insights into understanding AF pathogenesis and designing novel genetic therapies for AF patients.

Dataset Information

SNP rs3825214 in TBX5 is associated with lone atrial fibrillation in Chinese Han population.

Background

Methodology/principal findings

Conclusions

Publications

SNP rs3825214 in TBX5 is associated with lone atrial fibrillation in Chinese Han population.

Similar Datasets

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