Ontology highlight
ABSTRACT:
SUBMITTER: Chu WT
PROVIDER: S-EPMC3667132 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Chu Wen-Ting WT Zhang Ji-Long JL Zheng Qing-Chuan QC Chen Lin L Zhang Hong-Xing HX
PloS one 20130529 5
Src-homology regions 3 (SH3) domain is essential for the down-regulation of tyrosine kinase activity. Mutation A39V/N53P/V55L of SH3 is found to be relative to the urgent misfolding diseases. To gain insight, the human and gallus SH3 domains (PDB ID: 1NYG and 2LP5), including 58 amino acids in each protein, were selected for MD simulations (Amber11, ff99SB force field) and cluster analysis to investigate the influence of mutations on the spatial structure of the SH3 domain. It is found that the ...[more]