Ontology highlight
ABSTRACT:
SUBMITTER: Jin K
PROVIDER: S-EPMC3667947 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Human vaccines & immunotherapeutics 20121110 1
A DNA vaccination approach was used in the current study to screen for the immunogenicity of different fragments of toxin A and toxin B from Clostridium difficile. With this approach, protein antigens do not need to be produced in vitro and the immunogenicity of candidate C. difficile antigens can be identified directly in animals. Codon optimized toxin gene fragments were individually cloned into the DNA vaccine vector and tested in mice and rabbits for their ability to elicit C. difficile toxi ...[more]