Ontology highlight
ABSTRACT:
SUBMITTER: Lopes J
PROVIDER: S-EPMC3668035 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Lopes Joshua J Adiguzel Eser E Gu Steven S Liu Shu-Lin SL Hou Guangpei G Heximer Scott S Assoian Richard K RK Bendeck Michelle P MP
The American journal of pathology 20130406 6
Collagens in the atherosclerotic plaque signal regulation of cell behavior and provide tensile strength to the fibrous cap. Type VIII collagen, a short-chain collagen, is up-regulated in atherosclerosis; however, little is known about its functions in vivo. We studied the response to arterial injury and the development of atherosclerosis in type VIII collagen knockout mice (Col8(-/-) mice). After wire injury of the femoral artery, Col8(-/-) mice had decreased vessel wall thickening and outward r ...[more]