Ontology highlight
ABSTRACT:
SUBMITTER: Mace EM
PROVIDER: S-EPMC4961740 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Mace Emily M EM Gunesch Justin T JT Dixon Amera A Orange Jordan S JS
Nature communications 20160720
While distinct stages of natural killer (NK) cell development have been defined, the molecular interactions that shape human NK cell maturation are poorly understood. Here we define intercellular interactions between developing NK cells and stromal cells which, through contact-dependent mechanisms, promote the generation of mature, functional human NK cells from CD34(+) precursors. We show that developing NK cells undergo unique, developmental stage-specific sustained and transient interactions ...[more]