Memantine, an NMDA receptor antagonist, differentially influences Go/No-Go performance and fMRI activity in individuals with and without a family history of alcoholism.

ABSTRACT:

Rationale

Individuals with a family history of alcoholism (family history positive [FHP]) show higher alcoholism rates and are more impulsive than those without such a family history (family history negative [FHN]), possibly due to altered N-methyl-D-aspartate (NMDA) receptor function.

Objectives

We investigated whether memantine, an NMDA receptor antagonist, differentially influences impulsivity measures and Go/No-Go behavior and fMRI activity in matched FHP and FHN individuals.

Methods

On separate days, participants received a single dose of 40 mg memantine or identical-appearing placebo.

Results

No group performance differences were observed on placebo for Go correct hit or No-Go false alarm reaction time on the Go/No-Go task. During fMRI, right cingulate ac

SUBMITTER: Jamadar S 

PROVIDER: S-EPMC3674025 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature