Variation in OPRM1 and risk of suicidal behavior in drug-dependent individuals.
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ABSTRACT:
SUBMITTER: Arias AJ
PROVIDER: S-EPMC3674102 | biostudies-literature | 2012 Jan-Feb
REPOSITORIES: biostudies-literature
Publications
Variation in OPRM1 and risk of suicidal behavior in drug-dependent individuals.
Arias Albert J AJ Chan Grace G Gelernter Joel J Farrer Lindsay L Kranzler Henry R HR
The American journal on addictions 20111215 1
Completed suicide and nonfatal suicide-related outcomes (SROs), such as suicidal ideation and attempts, are heritable. A recent genetic association study in a sample of suicide victims reported a protective effect of the G allele of Asn40Asp (rs1799971) on risk for completed suicide. We examined the association of three OPRM1 single nucleotide polymorphisms (SNPs) (rs1799971, rs609148, and rs648893) with SRO in 426 European Americans, using GEE logistic regression analysis to examine the associa ...[more]
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