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Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease.

ABSTRACT: CD4(+)CD25(high)CD127(low/-) forkhead box p3 (Foxp3)(+) regulatory T cells (T(reg) cells) possess functional plasticity. Here we describe a higher frequency of T helper type 1 (T(H)1)-like, interferon-? (IFN-?)-secreting Foxp3(+) T cells in untreated subjects with relapsing remitting multiple sclerosis (RRMS) as compared to healthy control individuals. In subjects treated with IFN-?, the frequency of IFN-?(+)Foxp3(+) T cells is similar to that in healthy control subjects. In vitro, human T(reg) cells from healthy subjects acquire a T(H)1-like phenotype when cultured in the presence of interleukin-12 (IL-12). T(H)1-like T(reg) cells show reduced suppressive activity in vitro, which can partially be reversed by IFN-?-specific antibodies or by removal of IL-12.

SUBMITTER: Dominguez-Villar M

PROVIDER: S-EPMC3675886 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature

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Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease.

Dominguez-Villar Margarita M Baecher-Allan Clare M CM Hafler David A DA

Nature medicine 20110503 6

CD4(+)CD25(high)CD127(low/-) forkhead box p3 (Foxp3)(+) regulatory T cells (T(reg) cells) possess functional plasticity. Here we describe a higher frequency of T helper type 1 (T(H)1)-like, interferon-γ (IFN-γ)-secreting Foxp3(+) T cells in untreated subjects with relapsing remitting multiple sclerosis (RRMS) as compared to healthy control individuals. In subjects treated with IFN-β, the frequency of IFN-γ(+)Foxp3(+) T cells is similar to that in healthy control subjects. In vitro, human T(reg) ...[more]

PMID: 21540856

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