Ontology highlight
ABSTRACT:
SUBMITTER: Dominguez-Villar M
PROVIDER: S-EPMC3675886 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Dominguez-Villar Margarita M Baecher-Allan Clare M CM Hafler David A DA
Nature medicine 20110503 6
CD4(+)CD25(high)CD127(low/-) forkhead box p3 (Foxp3)(+) regulatory T cells (T(reg) cells) possess functional plasticity. Here we describe a higher frequency of T helper type 1 (T(H)1)-like, interferon-γ (IFN-γ)-secreting Foxp3(+) T cells in untreated subjects with relapsing remitting multiple sclerosis (RRMS) as compared to healthy control individuals. In subjects treated with IFN-β, the frequency of IFN-γ(+)Foxp3(+) T cells is similar to that in healthy control subjects. In vitro, human T(reg) ...[more]