Ontology highlight
ABSTRACT:
SUBMITTER: Tartar DM
PROVIDER: S-EPMC2843758 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Tartar Danielle M DM VanMorlan Amie M AM Wan Xiaoxiao X Guloglu F Betul FB Jain Renu R Haymaker Cara L CL Ellis Jason S JS Hoeman Christine M CM Cascio Jason A JA Dhakal Mermagya M Oukka Mohamed M Zaghouani Habib H
Journal of immunology (Baltimore, Md. : 1950) 20100224 7
Recently, traces of double-positive FoxP3(+)RORgammat(+) T cells were identified and viewed as dual programming differentiation intermediates geared toward development into T regulatory or Th17 cells. In this study, we report that FoxP3(+)RORgammat(+) intermediates arise in the NOD mouse T cell repertoire prior to inflammation and can be expanded with tolerogen without further differentiation. Furthermore, FoxP3(+)RORgammat(+) cells express both CD62L and membrane-bound TGFbeta and use the forme ...[more]