Ontology highlight
ABSTRACT:
SUBMITTER: Hong R
PROVIDER: S-EPMC3676104 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Hong Ran R Bai Weiya W Zhai Jianwei J Liu Wei W Li Xinyan X Zhang Jiming J Cui Xiaoxian X Zhao Xue X Ye Xiaoli X Deng Qiang Q Tiollais Pierre P Wen Yumei Y Liu Jing J Xie Youhua Y
Journal of virology 20130403 12
Hepatitis B virus (HBV) has extremely restricted host and hepatocyte tropism. HBV-based vectors could form the basis of novel therapies for chronic hepatitis B and other liver diseases and would also be invaluable for the study of HBV infection. Previous attempts at developing HBV-based vectors encountered low yields of recombinant viruses and/or lack of sufficient infectivity/cargo gene expression in primary hepatocytes, which hampered follow-up applications. In this work, we constructed a nove ...[more]