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Simple synthesis of pyrrolo[3,2-e]indole-1-carbonitriles.

ABSTRACT: Alkylation of 5-nitroindol-4-ylacetonitriles with ethyl chloroacetate, ?-halomethyl ketones, and chloroacetonitrile followed by a treatment of the products with chlorotrimethylsilane in the presence of DBU gives 1-cyanopyrrolo[3,2-e]indoles substituted in position 2 with electron-withdrawing groups.

SUBMITTER: Trawczynski A

PROVIDER: S-EPMC3678543 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Simple synthesis of pyrrolo[3,2-e]indole-1-carbonitriles.

Trawczyński Adam A Bujok Robert R Wróbel Zbigniew Z Wojciechowski Krzysztof K

Beilstein journal of organic chemistry 20130515

Alkylation of 5-nitroindol-4-ylacetonitriles with ethyl chloroacetate, α-halomethyl ketones, and chloroacetonitrile followed by a treatment of the products with chlorotrimethylsilane in the presence of DBU gives 1-cyanopyrrolo[3,2-e]indoles substituted in position 2 with electron-withdrawing groups. ...[more]

PMID: 23766809

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