Ontology highlight
ABSTRACT:
SUBMITTER: Cen B
PROVIDER: S-EPMC3680595 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Cen Bo B Mahajan Sandeep S Wang Wenxue W Kraft Andrew S AS
Cancer research 20130412 11
The PI3K/AKT pathway is hyperactivated in prostate cancer but its effective therapeutic targeting has proven difficult. In particular, the antitumor activity of AKT inhibitors is attenuated by upregulation of receptor tyrosine kinases (RTK) through an uncharacterized feedback mechanism. In this report, we show that RNA interference-mediated silencing or pharmacologic inhibition of Pim-1 activity curtails AKT inhibitor-induced upregulation of RTKs in prostate cancer cells. Although Pim kinases ha ...[more]