Ontology highlight
ABSTRACT:
SUBMITTER: Pignatelli J
PROVIDER: S-EPMC3462795 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Pignatelli Jeanine J Jones Matthew C MC LaLonde David P DP Turner Christopher E CE
PloS one 20121002 10
Cell adhesion to the extracellular matrix is a key event in cell migration and invasion and endocytic trafficking of adhesion receptors and signaling proteins plays a major role in regulating these processes. Beta2-adaptin is a subunit of the AP-2 complex and is involved in clathrin-mediated endocytosis. Herein, β2-adaptin is shown to bind to the focal adhesion protein actopaxin and localize to focal adhesions during cells spreading in an actopaxin dependent manner. Furthermore, β2-adaptin is en ...[more]