Ontology highlight
ABSTRACT:
SUBMITTER: Ferguson BS
PROVIDER: S-EPMC3683796 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Ferguson Bradley S BS Harrison Brooke C BC Jeong Mark Y MY Reid Brian G BG Wempe Michael F MF Wagner Florence F FF Holson Edward B EB McKinsey Timothy A TA
Proceedings of the National Academy of Sciences of the United States of America 20130529 24
Cardiac hypertrophy is a strong predictor of morbidity and mortality in patients with heart failure. Small molecule histone deacetylase (HDAC) inhibitors have been shown to suppress cardiac hypertrophy through mechanisms that remain poorly understood. We report that class I HDACs function as signal-dependent repressors of cardiac hypertrophy via inhibition of the gene encoding dual-specificity phosphatase 5 (DUSP5) DUSP5, a nuclear phosphatase that negatively regulates prohypertrophic signaling ...[more]