Ontology highlight
ABSTRACT:
SUBMITTER: Tahir SA
PROVIDER: S-EPMC3688259 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Tahir Salahaldin A SA Yang Guang G Goltsov Alexei A Song Ki-Duk KD Ren Chengzhen C Wang Jianxiang J Chang Wenjun W Thompson Timothy C TC
Cancer research 20130109 6
Caveolin 1 (Cav-1) is a plasma membrane-associated protein with the capacity to modulate signaling activities in a context-dependent fashion. Interactions between Cav-1 and low-density lipoprotein receptor-related protein 6 (LRP6) were reported to be important for the regulation of Wnt-β-catenin (β-cat) signaling. Cav-1 also interacts with insulin and IGF-I receptors (IGF-IR/IR) and can stimulate IR kinase activities. We found positive correlation between Cav-1 and LRP6 expression in both human ...[more]