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Vitamin D in cutaneous carcinogenesis: part I.

ABSTRACT: Skin cancer is the most common cancer in the United States. Exposure to ultraviolet radiation is a known risk factor for skin cancer but is also the principal means by which the body obtains vitamin D. Several studies have suggested that vitamin D plays a protective role in a variety of internal malignancies. With regard to skin cancer, epidemiologic and laboratory studies suggest that vitamin D and its metabolites may have a similar protective effect. These noncalcemic actions of vitamin D have called into question whether the current recommended intake of vitamin D is too low for optimal health and cancer prevention. Part I will review the role of vitamin D in the epidermis; part II will review the role of vitamin D in keratinocyte-derived tumors to help frame the discussion on the possible role of vitamin D in the prevention of skin cancer.

SUBMITTER: Tang JY

PROVIDER: S-EPMC3688468 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature

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Vitamin D in cutaneous carcinogenesis: part I.

Tang Jean Y JY Fu Teresa T Lau Christopher C Oh Dennis H DH Bikle Daniel D DD Asgari Maryam M MM

Journal of the American Academy of Dermatology 20121101 5

Skin cancer is the most common cancer in the United States. Exposure to ultraviolet radiation is a known risk factor for skin cancer but is also the principal means by which the body obtains vitamin D. Several studies have suggested that vitamin D plays a protective role in a variety of internal malignancies. With regard to skin cancer, epidemiologic and laboratory studies suggest that vitamin D and its metabolites may have a similar protective effect. These noncalcemic actions of vitamin D have ...[more]

PMID: 23062903

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