Ontology highlight
ABSTRACT:
SUBMITTER: Najumudeen AK
PROVIDER: S-EPMC3688908 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Najumudeen Arafath Kaja AK Köhnke Monika M Solman Maja M Alexandrov Kirill K Abankwa Daniel D
PloS one 20130618 6
Hundreds of eukaryotic signaling proteins require myristoylation to functionally associate with intracellular membranes. N-myristoyl transferases (NMT) responsible for this modification are established drug targets in cancer and infectious diseases. Here we describe NANOMS (NANOclustering and Myristoylation Sensors), biosensors that exploit the FRET resulting from plasma membrane nanoclustering of myristoylated membrane targeting sequences of Gαi2, Yes- or Src-kinases fused to fluorescent protei ...[more]