Ontology highlight
ABSTRACT:
SUBMITTER: Best JA
PROVIDER: S-EPMC3689652 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Best J Adam JA Blair David A DA Knell Jamie J Yang Edward E Mayya Viveka V Doedens Andrew A Dustin Michael L ML Goldrath Ananda W AW
Nature immunology 20130210 4
After infection, many factors coordinate the population expansion and differentiation of CD8+ effector and memory T cells. Using data of unparalleled breadth from the Immunological Genome Project, we analyzed the CD8+ T cell transcriptome throughout infection to establish gene-expression signatures and identify putative transcriptional regulators. Notably, we found that the expression of key gene signatures can be used to predict the memory-precursor potential of CD8+ effector cells. Long-lived ...[more]