Ontology highlight
ABSTRACT:
SUBMITTER: Zammit DJ
PROVIDER: S-EPMC2857562 | biostudies-literature | 2005 May
REPOSITORIES: biostudies-literature
Zammit David J DJ Cauley Linda S LS Pham Quynh-Mai QM Lefrançois Leo L
Immunity 20050501 5
Costimulatory signals from dendritic cells (DCs) are required for naive T cells to respond to antigenic stimulation. To what extent DCs reactivate memory T cells during recall responses is not known. Here, an in vivo depletion system has been used to analyze the role of DCs in reactivating CD8 memory T cells during recall responses to three different microbial infections. We show a profound decrease in the numbers of responding memory CD8 T cells in both lymphoid and nonlymphoid tissues during t ...[more]