Plasma lipid metabolites are associated with gestational age but not bronchopulmonary dysplasia.

ABSTRACT: To test the hypothesis that plasma lipid metabolite levels in premature infants are associated with the development of bronchopulmonary dysplasia (BPD). The studies also tested a secondary hypothesis that plasma lipid metabolite levels were correlated with gestational age.Infants born <32 weeks' gestation were enrolled during the first 72 h of life. Plasma samples were obtained and lipid levels were measured by LC-MS/MS. Clinical data were collected to determine infant outcomes and BPD diagnosis.Following adjustment for confounders, lipid levels were not associated with BPD; however, levels of specific lipid metabolites were correlated with gestational age.Immature lipid metabolism pathways in premature infants may contribute to the pathogenesis of BPD and other diseases.

SUBMITTER: Rogers LK 

PROVIDER: S-EPMC3693574 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature