Ontology highlight
ABSTRACT:
SUBMITTER: Moriev R
PROVIDER: S-EPMC3695357 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Moriev R R Vasylchenko O O Platonov M M Grygorenko O O Volkova K K Zozulya S S
Acta naturae 20130401 2
The aim of this study was to identify small molecule compounds that inhibit the kinase activity of the IGF1 receptor and represent novel chemical scaffolds, which can be potentially exploited to develop drug candidates that are superior to the existing experimental anti-IGF1R therapeuticals. To this end, targeted compound libraries were produced by virtual screening using molecular modeling and docking strategies, as well as the ligand-based pharmacophore model. High-throughput screening of the ...[more]