Ontology highlight
ABSTRACT:
SUBMITTER: Gil-Farina I
PROVIDER: S-EPMC3699534 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Gil-Fariña Irene I Di Scala Marianna M Vanrell Lucia L Olagüe Cristina C Vales Africa A High Katherine A KA Prieto Jesus J Mingozzi Federico F Gonzalez-Aseguinolaza Gloria G
PloS one 20130702 7
Recombinant adenoassociated viral vectors (rAAV) have proven to be excellent candidates for gene therapy clinical applications. Recent results showed that cellular immunity to AAV represents a major challenge facing the clinical use of systemic administration of these vectors. Interestingly, no preclinical animal model has previously fully reproduced the clinical findings. The aim of the present work was to enhance the T cell immune response against AAV capsid in mice by the administration of a ...[more]