Ontology highlight
ABSTRACT:
SUBMITTER: Montes VN
PROVIDER: S-EPMC3699637 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Montes Vince N VN Turner Michael S MS Subramanian Savitha S Ding Yilei Y Hayden-Ledbetter Martha M Slater Sonya S Goodspeed Leela L Wang Shari S Omer Mohamed M Den Hartigh Laura J LJ Averill Michelle M MM O'Brien Kevin D KD Ledbetter Jeffrey J Chait Alan A
PloS one 20130702 7
Adipose tissue inflammation and specifically, pro-inflammatory macrophages are believed to contribute to insulin resistance (IR) in obesity in humans and animal models. Recent studies have invoked T cells in the recruitment of pro-inflammatory macrophages and the development of IR. To test the role of the T cell response in adipose tissue of mice fed an obesogenic diet, we used two agents (CTLA-4 Ig and anti-CD40L antibody) that block co-stimulation, which is essential for full T cell activation ...[more]