Ontology highlight
ABSTRACT:
SUBMITTER: Howell SC
PROVIDER: S-EPMC3699757 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Howell Steven C SC Andresen Kurt K Jimenez-Useche Isabel I Yuan Chongli C Qiu Xiangyun X
Biophysical journal 20130701 1
The nucleosome is the first level of genome organization and regulation in eukaryotes where negatively charged DNA is wrapped around largely positively charged histone proteins. Interaction between nucleosomes is dominated by electrostatics at long range and guided by specific contacts at short range, particularly involving their flexible histone tails. We have thus quantified how internucleosome interactions are modulated by salts (KCl, MgCl2) and histone tail deletions (H3, H4 N-terminal), usi ...[more]