Ontology highlight
ABSTRACT:
SUBMITTER: O'Donoghue GP
PROVIDER: S-EPMC3701909 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
O'Donoghue Geoff P GP Pielak Rafal M RM Smoligovets Alexander A AA Lin Jenny J JJ Groves Jay T JT
eLife 20130703
T cells discriminate between self and foreign antigenic peptides, displayed on antigen presenting cell surfaces, via the TCR. While the molecular interactions between TCR and its ligands are well characterized in vitro, quantitative measurements of these interactions in living cells are required to accurately resolve the physical mechanisms of TCR signaling. We report direct single molecule measurements of TCR triggering by agonist pMHC in hybrid junctions between live primary T cells and suppor ...[more]