Age-changes in gene expression in primary mixed glia cultures from young vs. old rat cerebral cortex are modified by interactions with neurons.
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ABSTRACT:
SUBMITTER: Kremsky I
PROVIDER: S-EPMC3703782 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Publications
Age-changes in gene expression in primary mixed glia cultures from young vs. old rat cerebral cortex are modified by interactions with neurons.
Kremsky Isaac I Morgan Todd E TE Hou Xiaogang X Li Lei L Finch Caleb E CE
Brain, behavior, and immunity 20111228 5
Astrocytic GFAP expression increases during normal aging in many brain regions and in primary astrocyte cultures derived from aging rodent brains. As shown below, we unexpectedly found that the age-related increase of GFAP expression was suppressed in mixed glia (astrocytes+microglia). However, the age-related increase of GFAP was observed when E18 neurons were co-cultured with mixed glia. Thus, the presence of microglia can suppress the age-related increase of GFAP, in primary cultures of astro ...[more]
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