Ontology highlight
ABSTRACT:
SUBMITTER: Miao Y
PROVIDER: S-EPMC3703993 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Miao Yinglong Y Nichols Sara E SE Gasper Paul M PM Metzger Vincent T VT McCammon J Andrew JA
Proceedings of the National Academy of Sciences of the United States of America 20130618 27
G-protein-coupled receptors (GPCRs) mediate cellular responses to various hormones and neurotransmitters and are important targets for treating a wide spectrum of diseases. Although significant advances have been made in structural studies of GPCRs, details of their activation mechanism remain unclear. The X-ray crystal structure of the M2 muscarinic receptor, a key GPCR that regulates human heart rate and contractile forces of cardiomyocytes, was determined recently in an inactive antagonist-bo ...[more]