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Moderate to vigorous physical activity interactions with genetic variants and body mass index in a large US ethnically diverse cohort.

ABSTRACT: BACKGROUND:Little is known about the interaction between genetic and behavioural factors during lifecycle risk periods for obesity and how associations vary across race/ethnicity. OBJECTIVE:The objective of this study was to examine joint associations of adiposity-related single-nucleotide polymorphisms (SNPs) and moderate to vigorous physical activity (MVPA) with body mass index (BMI) in a diverse adolescent cohort. METHODS:Using data from the National Longitudinal Study of Adolescent Health (n?=?8113: Wave II 1996; ages 12-21, Wave III; ages 18-27), we assessed interactions of 41 well-established SNPs and MVPA with BMI-for-age Z-scores in European Americans (EA; n?=?5077), African-Americans (AA; n?=?1736) and Hispanic Americans (HA; n?=?1300). RESULTS:Of 97 assessed, we found nominally significant SNP-MVPA interactions on BMI-for-age Z-score in EA at GNPDA2 and FTO and in HA at LZTR2/SEC16B. In EA, the estimated effect of the FTO risk allele on BMI-for-age Z-score was lower (??=?-0.13; 95% confidence interval [CI]: 0.08, 0.18) in individuals with ?5 vs. <5 (??=?0.24; CI: 0.16, 0.32) bouts of MVPA per week (P for interaction 0.02). Race/ethnicity-pooled meta-analysis showed nominally significant interactions for SNPs at TFAP2B, POC5 and LYPLAL1. CONCLUSIONS:High MVPA may attenuate underlying genetic risk for obesity during adolescence, a high-risk period for adult obesity.

SUBMITTER: Richardson AS

PROVIDER: S-EPMC3707946 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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Moderate to vigorous physical activity interactions with genetic variants and body mass index in a large US ethnically diverse cohort.

Richardson A S AS North K E KE Graff M M Young K M KM Mohlke K L KL Lange L A LA Lange E M EM Harris K M KM Gordon-Larsen P P

Pediatric obesity 20130325 2

<h4>Background</h4>Little is known about the interaction between genetic and behavioural factors during lifecycle risk periods for obesity and how associations vary across race/ethnicity.<h4>Objective</h4>The objective of this study was to examine joint associations of adiposity-related single-nucleotide polymorphisms (SNPs) and moderate to vigorous physical activity (MVPA) with body mass index (BMI) in a diverse adolescent cohort.<h4>Methods</h4>Using data from the National Longitudinal Study o ...[more]

PMID: 23529959

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Project description:BackgroundAlthough obesity has been hypothesized to worsen asthma, data from studies of subjects with well-characterized asthma are lacking.ObjectiveWe sought to evaluate the relationship between body mass index (BMI), asthma impairment, and response to therapy.MethodsBMI (in kilograms per meter squared) and asthma phenotypic and treatment response data were extracted from Asthma Clinical Research Network studies. The cross-sectional relationship between BMI and asthma impairment was analyzed, as was the longitudinal relationship between BMI and response to asthma controller therapies.ResultsOne thousand two hundred sixty-five subjects with mild-to-moderate persistent asthma were evaluated. Analyses of lean versus overweight/obese asthmatic subjects demonstrated small differences in FEV1 (3.05 vs 2.91 L, P = .001), FEV1/forced vital capacity ratio (mean, 83.5% vs 82.4%; P = .01), rescue albuterol use (1.1 vs 1.2 puffs per day, P = .03), and asthma-related quality of life (5.77 vs 5.59, P = .0004). Overweight/obese asthmatic subjects demonstrated a smaller improvement in exhaled nitric oxide levels with inhaled corticosteroid (ICS) treatment than did lean asthmatic subjects (3.6 vs 6.5 ppb, P = .04). With ICS/long-acting beta-agonist treatment, overweight/obese asthmatic subjects demonstrated smaller improvements in lung function than lean asthmatic subjects, with an 80 mL (P = .04) and 1.7% (P = .02) lesser improvement in FEV1 and FEV1/forced vital capacity ratio, respectively. Significant differences in therapeutic response to leukotriene modifiers between BMI categories were not observed.ConclusionsIncreased BMI is not associated with clinically significant worsening of impairment in subjects with mild-to-moderate persistent asthma. There is a modest association between increased BMI and reduced therapeutic effect of ICS-containing regimens in this patient population. Prospective studies evaluating the effect of being overweight or obese on treatment response in asthma are warranted.

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Moderate to vigorous physical activity interactions with genetic variants and body mass index in a large US ethnically diverse cohort.

Publications

Moderate to vigorous physical activity interactions with genetic variants and body mass index in a large US ethnically diverse cohort.

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