Ontology highlight
ABSTRACT:
SUBMITTER: Wei Z
PROVIDER: S-EPMC3710815 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Wei Zhiyi Z Liu Xiaotian X Yu Cong C Zhang Mingjie M
Proceedings of the National Academy of Sciences of the United States of America 20130624 28
Class V myosins (MyoV), the most studied unconventional myosins, recognize numerous cargos mainly via the motor's globular tail domain (GTD). Little is known regarding how MyoV-GTD recognizes such a diverse array of cargos specifically. Here, we solved the crystal structures of MyoVa-GTD in its apo-form and in complex with two distinct cargos, melanophilin and Rab interacting lysosomal protein-like 2. The apo-MyoVa-GTD structure indicates that most mutations found in patients with Griscelli synd ...[more]