Ontology highlight
ABSTRACT:
SUBMITTER: Kato H
PROVIDER: S-EPMC3711048 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Kato Hiroaki H Okazaki Kosuke K Iida Tetsushi T Nakayama Jun-Ichi J Murakami Yota Y Urano Takeshi T
Scientific reports 20130101
The tail of histone H3 is an ideal medium for storing epigenetic information because displacement of histone H3 is heavily restricted during transcription. To maintain the locus-specific modifications of histone H3, histone molecules should be retained locally at the original position through multiple rounds of transcription. Here, we found that fission yeast Spt6, a highly conserved RNA polymerase II-interacting histone H3-H4 chaperone, is essential for the maintenance of Lys-4 and Lys-9 methyl ...[more]