Ontology highlight
ABSTRACT:
SUBMITTER: Bester AC
PROVIDER: S-EPMC3711054 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Bester Assaf C AC Kafri Moshe M Maoz Karin K Kerem Batsheva B
Scientific reports 20130101
Genome instability is a hallmark of cancer. Common fragile sites (CFSs) are specific regions in the human genome that are sensitive to replication stress and are prone to genomic instability in different cancer types. Here we molecularly cloned a new CFS, FRA11H, in 11q13. The genomic region of FRA11H harbors a hotspot of chromosomal breakpoints found in different types of cancer, indicating that this region is unstable during cancer development. We further found that FRA11H is a hotspot for int ...[more]