Ontology highlight
ABSTRACT:
SUBMITTER: Nam JS
PROVIDER: S-EPMC6278723 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Nam Jung-Soo JS Lee Ji-Eun JE Lee Kwang-Hee KH Yang Yeji Y Kim Soo-Hyun SH Bae Gyu-Un GU Noh Hohsuk H Lim Kwang-Il KI
Molecular therapy. Methods & clinical development 20181113
The unique ability of retroviruses to integrate genes into host genomes is of great value for long-term expression in gene therapy, but only when integrations occur at safe genomic sites. To reap the benefit of using retroviruses without severe detrimental effects, we developed several murine leukemia virus (MLV)-based gammaretroviral vectors with safer integration patterns by perturbing the structure of the integrase via insertion of DNA-binding zinc-finger domains (ZFDs) into an internal posit ...[more]