Ontology highlight
ABSTRACT:
SUBMITTER: McEwen GK
PROVIDER: S-EPMC7910482 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
McEwen Gayle K GK Alquezar-Planas David E DE Dayaram Anisha A Gillett Amber A Tarlinton Rachael R Mongan Nigel N Chappell Keith J KJ Henning Joerg J Tan Milton M Timms Peter P Young Paul R PR Roca Alfred L AL Greenwood Alex D AD
Nature communications 20210226 1
Repeated retroviral infections of vertebrate germlines have made endogenous retroviruses ubiquitous features of mammalian genomes. However, millions of years of evolution obscure many of the immediate repercussions of retroviral endogenisation on host health. Here we examine retroviral endogenisation during its earliest stages in the koala (Phascolarctos cinereus), a species undergoing germline invasion by koala retrovirus (KoRV) and affected by high cancer prevalence. We characterise KoRV integ ...[more]